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ARTICLE | Clinical News

Aslan dips after Phase II gastric cancer miss

January 14, 2019 3:08 PM UTC

Aslan Pharmaceuticals Ltd. (TPEx:6497; NASDAQ:ASLN) said its pan-HER inhibitor varlitinib missed the primary endpoint of a Phase II trial to treat gastric cancer. Aslan shares slid $2.75 (10%) to $24.90 in Taipei on Monday, and its ADSs were off $0.14 to $3.41 on NASDAQ.

The study evaluated varlitinib as a first-line therapy in patients with advanced or metastatic disease, co-expressing EGFR and HER2. On the primary endpoint, varlitinib plus mFOLFOX6 chemotherapy failed to significantly reduce tumor size after 12 weeks of treatment vs. mFOLFOX6 alone (22% vs. 12.5%). Aslan said that after reviewing 17 progression-free survival (PFS) events to date, a trend toward improvement in PFS favored the varlitinib group...

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Aslan Pharmaceuticals Ltd.