Vascular endothelial stem cells could enable regenerative therapy
In a study published in Cell Stem Cell, researchers at Osaka University and colleagues discovered a population of vascular endothelial cells that could be used as a regenerative therapy for vascular injury and hemophilia.
The existence of tissue-resident vascular endothelial stem cells (VESCs) and their role in angiogenesis had been under debate -- many in the field believed angiogenesis in adults is initiated by mature resident endothelial cells. Through a series of flow cytometry and gene expression analyses, followed by primary mouse cell culture and mouse transplantation experiments, the researchers identified a population of endothelial cells with stem cell properties...
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