University of Basel team suggests LHPP as tumor suppressor

In a paper published in Nature, researchers at the University of Basel suggest that phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) could help treat liver cancer.

While histidine phosphorylation is known to be part of signaling pathways in fungi and bacteria, its function in higher eukaryotes is poorly characterized, and a role for this protein modification in cancer had not yet been reported...