BioCentury
ARTICLE | Preclinical News

Targeting neuraminidase could improve flu vaccine

April 9, 2018 3:04 PM UTC

A paper in Cell proposes a new strategy to develop an influenza vaccine exploiting the less targeted surface glycoprotein neuraminidase.

Efforts to produce effective influenza vaccines have mainly focused on inhibiting hemagglutinin, the more abundant of the two main surface glycoproteins on the influenza virus. Studies have suggested that hemagglutinin's antigenic drift is the primary reason for the limited effectiveness of the seasonal influenza vaccine...