SNS nerve loss drives hematopoietic stem cell aging

A paper published in Nature Medicine showed that the loss of sympathetic nervous system (SNS)nerves in bone marrow is a driver of hematopoietic stem cell (HSC) aging, suggesting that agonizing the receptors targeted by SNS-delivered neurotransmitters can “rejuvenate” HSCs during aging.

HSCs, which reside in a microenvironment in the bone marrow, lose their capacity to regenerate and differentiate into multiple lineages as they age, which can lead to blood disorders...