BioCentury
ARTICLE | Preclinical News

Preventing DNA repair blocks inflammation

November 16, 2018 1:23 PM UTC

In Science, researchers at Karolinska Institute and colleagues reported a new approach to treat inflammatory diseases by blocking repair of inflammation-induced oxidative DNA damage.

Reactive oxygen species (ROS) generated by inflammation induce oxidative DNA damage. The enzyme 8-oxoguanine DNA glycosylase (OGG1; HMMH) binds oxidized guanine to initiate repair of DNA damaged by oxidative stress, which in turn promotes inflammation by recruiting transcription factors that drive expression of proinflammatory genes...