BioCentury
ARTICLE | Preclinical News

Engineering allogeneic iPS cells to avoid transplant rejection

February 20, 2019 10:37 PM UTC

UCSF researchers have made headway toward developing universal allogeneic iPS cell therapies by identifying a dual mechanism that prevented immune rejection in mice.

Adult stem cells have shown limited efficacy as a regenerative strategy for treating heart disease because the cells have limited plasticity and cannot differentiate into cardiomyocytes. Induced pluripotent stem cells offer an unlimited source of progeny cells that can be differentiated into functional tissue cells for regenerative strategies, but pose roadblocks...