ARTICLE | Tools & Techniques
Disney lab uncovers another RNA-binding small molecule for triple-negative breast cancer
The Disney lab expands its RNA-binding small molecule toolbox with targeted RNA degradation
January 21, 2020 11:47 PM UTC
Matthew Disney is attacking triple-negative breast cancer again with the latest iteration of his RNA-binding small molecule technology, which marries the concept with targeted RNA degradation to eliminate disease-causing RNA segments.
In a paper published in the Proceedings of the National Academy of Sciences (PNAS) on Jan. 20, Disney and colleagues showed that a small molecule construct designed to degrade the precursor of oncogenic miR-21 prevented TNBC metastasis in mice...
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