BioCentury
ARTICLE | Distillery Techniques

Techniques: Transgenic mouse models of human chromosome 9 open reading frame 72 (C9orf72)-mutant amyotrophic lateral sclerosis (ALS) or frontotemporal dementia

April 28, 2016 7:00 AM UTC

Transgenic mice expressing repeat expansions of GGGGCC in human C9orf72 could be used to screen therapies for ALS or FTD. In mice, bacterial artificial chromosome (BAC)-mediated expression of either t...