Techniques: Mice with midbrain neuron-specific knockout of LIM homeobox transcription factor 1 α (LMX1A; LMX1) and LMX1B as a model of Parkinson's disease (PD)

LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD. In mice, knockout of LMX1A and LMX1B in midbrain dopaminergic neurons recapitulated the oxidative stress in midbrain neur...