BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Adenylate cyclase 5 (AC5)

March 17, 2016 7:00 AM UTC

Mouse and pig studies suggest inhibiting AC5 could help treat ischemia/reperfusion injury. In a mouse model of coronary artery occlusion, heart-specific knockout of AC5 decreased infarct size compared with normal AC5 expression. Also in the mouse model and in a pig model of coronary artery occlusion, the AC5 inhibitor vidarabine decreased infarct size compared with vehicle. Next steps include identifying and testing AC5 inhibitors with low toxicity in vivo to treat ischemia/reperfusion injury...