Therapeutics: Heat shock 70 kDa protein 1A (Hsp72; HspA1)

Rat studies suggest the Hsp72-inducer BGP-15 could help treat ventilation-induced diaphragm dysfunction (VIDD). In a mechanically ventilated rat model of VIDD, BGP-15 increased the specific force of diaphragm muscle fibers and myosin force generation capacity compared with no treatment. Next steps could include optimizing BGP-15 for restoration of normal diaphragm function...