Neurology

Mouse studies suggest a TrkB-agonizing BDNF peptide could help treat demyelination diseases. In a mouse model of CNS demyelination, intracerebroventricular infusion of a previously reported tricyclic BDNF peptide agonist of TrkB (EC₅₀ = 11 pM) increased the number of oligodendrocytes, the percentage of myelinated axons and the thickness of myelin sheaths in the corpus callosum compared with vehicle. Next steps include optimizing and testing the peptide in additional models of CNS demyelination disease...