Ophthalmic disease

Mouse studies suggest inhibiting TRPV4 or its downstream mediator MCP-1 could help treat retinal detachment. In a mouse model of retinal detachment, systemic or Müller glia- and astrocyte-specific TRPV4 knockout, a tool compound TRPV4 inhibitor or an anti-MCP-1 mAb decreased the number of dead photoreceptors compared with normal TRPV4 expression, no treatment or control IgG, respectively. Next steps include investigating the mechanism by which TRPV4 contributes to swelling in the indication. ...