Neurology

Cell culture and mouse studies suggest PARP inhibitors could help treat PD. In primary mouse cortical neurons cultured with α-synuclein fibrils, the PARP inhibitors veliparib, Rubraca rucaparib and Talzenna talazoparib decreased cell death compared with vehicle. In a mouse model of PD, PARP-1 knockout or veliparib decreased dopaminergic neuron death compared with normal PARP-1 expression or vehicle. Next steps could include testing PARP inhibitors in neurons from PD patients.

Clovis Oncology Inc. and Pfizer Inc. market Rubraca for ovarian cancer...