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Aelin is synthesizing antimicrobial peptides to induce protein aggregation in Gram-negative bacteria
May 3, 2018 7:34 PM UTC
Aelin Therapeutics N.V. is developing first-in-class synthetic peptides that could treat antibiotic-resistant Gram-negative infections by inducing toxic protein aggregation within bacterial cells.
By harnessing a novel mechanism of action that disrupts proteostasis, Aelin could circumvent growing resistance to existing antibiotics, which typically act by disrupting the bacterial cell membrane. ...
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Vascular endothelial growth factor (VEGF) receptor 2 (VEGFR-2) (KDR/Flk-1)