BioCentury
ARTICLE | Emerging Company Profile

Refuge: Receptive CAR checkpoints

How Refuge is using CRISPR to suppress checkpoint genes in CAR T cells

February 21, 2019 8:16 PM UTC

Refuge Biotechnologies Inc. aims to make CAR T cells more potent by suppressing their checkpoint genes and is using a form of CRISPR that knocks the genes down instead of out to improve safety.

CEO Bing Wang told BioCentury that like endogenous T cells, CAR T cell therapies also express checkpoint proteins that can limit their anti-tumor activity. ...