ARTICLE | Targets & Mechanisms
Not an open and shut helicase
May 7, 2009 7:00 AM UTC
Although the serine protease domain of HCV non-structural
protein 3 is one of the hottest targets in the antiviral space, little attention has been given to another enzymatic function on the same protein-a helicasethat unwinds viral DNA and RNA. One reason is that the structure of HCV helicase is similar to known human proteins, thus raising concerns about off-target effects...