ROS overload

Boston researchers have identified a molecule that kills tumors by taking the already high level of reactive oxygen species in cancer cells and upping it further. The molecule had efficacy in a wide range of mouse models of cancer,¹ and the scientists have formed Canthera Therapeutics Inc. to develop drug-like analogs and identify genetic biomarkers for predicting patient response.

The discovery of the reactive oxygen species (ROS)-boosting molecule started unexpectedly with a cell-based screen for compounds that could modulate p53 activity...