BioCentury
ARTICLE | Targets & Mechanisms

Promoting telomerase

February 21, 2013 8:00 AM UTC

Two independent teams have identified activating mutations in the promoter of telomerase reverse transcriptase that occur in more than 70% of melanoma cases.1,2 The findings highlight the still-untapped potential of analyzing noncoding regions of cancer genomes and offer a hint about how some malignancies develop.

The functional role of these mutations still needs to be further explored before their therapeutic relevance can be assessed...