BioCentury
ARTICLE | Targets & Mechanisms

Solid checkpoint for CARs

PD-L1 relative B7-H3 could help CAR T cells crack pediatric and solid tumors

February 22, 2019 4:45 AM UTC

PD-L1 family member B7-H3 could put CAR T cells in play for a slew of difficult-to-treat solid tumors, including pediatric cancers that lack targeted therapies, according to a pair of preclinical studies published this year. But questions around the target’s safety will call for close attention to the therapeutic window.

The findings, from Stanford University’s Crystal Mackall and University of North Carolina Chapel Hill’s Gianpietro Dotti, respectively, move B7-H3 up the flagpole from the class of new immuno-oncology targets to a potential difference-maker in enabling CAR Ts in new, highly underserved indications. ...