ARTICLE | Tools & Techniques
Scaling up iPS cells
January 10, 2013 8:00 AM UTC
A Memorial Sloan-Kettering Cancer Center team has conducted one of the first large-scale screens of a small molecule library using patient-derived induced pluripotent stem cells.1 The approach was applied to neuronal cells derived from patients with familial dysautonomia and provides early evidence of its potential for identifying new leads.
Separately, a public-private partnership led by Roche and the University of Oxford is aiming to establish a repository comprising 1,500 induced pluripotent stem (iPS) cells-triplicate samples from 500 patients with diabetes or a wide range of neurological diseases-in an effort to provide a tool for finding new targets and therapeutic leads...