Undiscovered country

Although total RNA sequencing can identify oncogenes caused by the fusion of two genes, the method is inefficient and costly because the transcripts from the abnormal genes are often rare. NuGen Technologies Inc. has developed an efficient sequencing technique that can find rare transcripts from fused genes, and can help clinicians identify driver mutations in cancer that might be missed with total RNA sequencing.

Douglas Amorese, VP of R&D at NuGen, said, "Conventional RNA sequencing requires 125 million reads in order to detect a particular gene fusion, and yet with our technology we are able to see gene fusions much more easily with many fewer reads."...