K follows C in chemoproteomics

A year after publishing a map of druggable cysteines in the proteome, Ben Cravatt’s lab at Scripps has reported its chemoproteomics tools can also profile lysines. By identifying reactive lysines in dozens of proteins for which no chemical probes exist, let alone candidate molecules, the group continues to expand the universe of druggable targets.

Chemoproteomics was largely pioneered by Cravatt, a professor of chemical physiology at The Scripps Research Institute who has developed a range of chemical tools for identifying specific types of reactive sites on proteins...