Ripe for enhancement

Although still largely the purview of academics, technologies for mapping enhancers to the genes they control are rapidly gaining efficiency and promise to unlock a trove of new targets for drug developers. But companies will need to contend with complex biology and screens that require primary human cells.

The progress adds another branch to the field of epigenetics, an area seeing revived interest in translational science as researchers find solutions in human data that answer mechanistic questions and guide drug discovery around HDACs, BET bromodomain proteins and emerging epigenetic targets. ...