BioCentury
ARTICLE | Translation in Brief

Finding the door

A high throughput method for mapping host-pathogen interactions

June 2, 2016 7:00 AM UTC

A team of U.S. and Israeli researchers has developed a high throughput assay that could solve a bottleneck in anti-infectives development: identifying the host cell receptors that pathogens use to gain entry.

High throughput screens of membrane receptors for protein-protein interactions have not had the success of soluble proteins because the molecules' low abundance makes them hard to purify from cells in large quantities, and extraction from membranes often causes them to misfold and become dysfunctional. ...