BioCentury
ARTICLE | Translation in Brief

Blueprint for fusion

Blueprint and Rockefeller find a fusion protein driver of a rare liver cancer

October 27, 2016 7:00 AM UTC

Blueprint Medicines Corp. (NASDAQ:BPMC) and researchers at The Rockefeller University are ramping up their collaboration to develop inhibitors of a disease-driving fusion protein found in all patients with fibrolamellar carcinoma, a rare subtype of hepatocellular carcinoma (HCC) for which the only available treatment option is surgical resection.

The partners joined forces in 2014, after independently identifying the fusion oncogene between protein kinase cAMP-dependent catalytic α (PRKACA) and DnaJ homolog subfamily B member 1 (DNAJB1) in patients with the cancer...