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ARTICLE | Translation in Brief

Engaging with exosomes

How USC’s exosomes could one-up T cell targeting antibodies

December 5, 2018 6:09 PM UTC

A University of Southern California team has developed synthetic exosomes that express multiple multivalent antibodies, giving them a function like T cell bispecific antibodies, but potentially higher avidity.

In a paper published in November in the Journal of the American Chemical Society, the team generated its synthetic multivalent antibodies retargeted exosomes (SMART-Exos) by transfecting HEK cells with a construct encoding a single-chain variable fragment (scFv) antibody targeting CD3 linked to an antibody targeting EGFR and an exosomal membrane protein. ...