ARTICLE | Translation in Brief
Accounting for microbial PK
Predicting the microbiome’s contribution to drug metabolism
February 21, 2019 6:27 PM UTC
A Yale University team has created a mathematical model that predicts how the gut microbiome contributes to drug metabolism, offering companies a way to factor microbiome-driven variability between patients into dosing, toxicity and PK studies.
Drug developers have historically ignored the role of the microbiome in breaking down drugs and producing metabolites...
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