BioCentury
ARTICLE | Clinical News

Influenza vaccines infectious data

October 31, 2011 7:00 AM UTC

Researchers at the university and colleagues reported data from a meta-analysis of 17 randomized controlled trials and 14 observational studies of approved influenza vaccines suggesting that the vaccines can provide moderate protection against virologically-confirmed influenza. However, the researchers said new influenza vaccines with improved clinical efficacy and effectiveness are needed to further reduce influenza-related morbidity and mortality. In the analysis, pooled efficacy for TIVs against influenza infection was 59% in healthy volunteers aged 18-65 years, whereas pooled efficacy for LAIVs was 83% in children aged 6 months to 7 years. The researchers did not find any trials for TIVs that met inclusion criteria for children aged 2-17 years or adults aged 65 years and older, and no trials for LAIVs met inclusion criteria for children aged 8-17 years. Furthermore, median monovalent pandemic H1N1 vaccine effectiveness in subjects aged less than 65 years in 5 observational studies was 69%. Data were published in The Lancet. ...