Anacor preclinical data

In a mouse model of stage 2 human African trypanosomiasis, once-daily 12.5 and 25 mg/kg oral SCYX-7158 given over 7 days starting on day 21 post-infection produced cure rates of 80% and 100%, respectively. Cure was defined as the lack of parasitemia in the blood for 180 days after the last dose, together with a lack of infection measured through 30 days in fresh animals inoculated with the blood and/or brain homogenates collected from SCYX-7158-treated animals. SCYX-7158 was well tolerated at doses of up to 200 mg/kg/day and exhibited good permeability across the blood-brain barrier (BBB). The oral small molecule benzoxaborole is expected to start Phase I testing this year. Data were presented at the BIO International Convention in Washington and published in PLoS Neglected Tropical Diseases. ...