Cortexyme's bacterial protease inhibitor improves AD signs in mice

Cortexyme Inc. (South San Francisco, Calif.) revealed in a Science Advances paper that lead product, COR388, slowed neurodegeneration in a mouse model of Alzheimer's disease.

COR388 inhibits the Porphyromonas gingivalis-derived lysine gingipain, a protease produced by the periodontitis-causing P. gingivalis...