Stopping chain swapping

By controlling how antibody chains pair, Elstar Therapeutics Inc.’s platform can produce multispecific antibodies at yields comparable to methods for manufacturing monospecific antibodies.

The company develops multispecific antibodies with up to four functional domains that bind tumor cells or modulate immune cells. The functional domains include single-chain variable fragments (scFvs), ligands, cytokines, cytokine traps and enzymes...