BioCentury
ARTICLE | Product Development

Metastatic target in the basement

May 19, 2008 7:00 AM UTC

Although researchers discovered in 1984 that the laminin receptor precursor/laminin receptor (LRP/LR) is overexpressed in tumor tissue compared with normal tissue, until recently there has been minimal interest because a basement membrane receptor involved in cell communication and adhesion didn't seem to be an attractive target.

Researchers from Affimed Therapeutics AG and colleagues have now shown that antibodies against LRP/LR inhibit the two key components of metastatic tumors: invasion and adhesion...