Ro 46-2005 blocker of endothelin-1 receptor data

Roche published in vitro data on an orally active, non-peptide inhibitor of endothelin-1, a naturally secreted factor which has long-lasting constricting effects on blood vessels. Ro 46-2005 reversibly and potently blocked the action of endothelin on isolated vascular tissues, without affecting the vascular contractions induced by other vasoconstrictors. ...