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ARTICLE | Targets & Mechanisms

Introducing GSAP

September 16, 2010 7:00 AM UTC

Following a lead provided by Gleevec, a team of U.S. researchers from The Rockefeller University and Intra-Cellular Therapies Inc. has identified a new regulatory protein, g-secretase activating protein, that activates g-secretase, a key Alzheimer's disease target.1

Because g-secretase activating protein (GSAP; PION) potentially regulates only the b-amyloid (Ab)-related activity of g-secretase, GSAP inhibitors might be safer than compounds that block all g-secretase activity. Intra-Cellular is developing small molecule compounds that can enter the brain and target GSAP...

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