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ARTICLE | Targets & Mechanisms

The GPCR-cancer connection

August 12, 2010 7:00 AM UTC

Researchers from Roche's Genentech Inc.unit have identified a host of somatic mutations and gene copy number alterations across human cancers that represent potential targets for the disease.1 Nineteen of the 112 candidate cancer genes identified are G protein-coupled receptors. With many of these receptors already being targeted in other indications, the path may be open to move rapidly on genes that are validated as cancer targets.

Although previous systematic efforts to sequence somatic mutations in cancer have resulted in new insights into the disease and the identification of new drug targets, these earlier efforts are believed to have only scratched the surface of the cancer genome.2...

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