Rejuvenating T cells

Two Japanese teams have used induced pluripotent stem cells to regenerate antigen-specific T cells in patients whose immune systems have been depleted.^1,2 Megakaryon Corp. is developing and commercializing the technology of one group to produce induced pluripotent stem cell-derived human T cells.

T cells play an important role in the host response to viral infections and cancer, but chronic exposure to viral or cancer antigens can drive T cells into an exhausted state in which they lose their effector function and capacity to proliferate...