Important: New Login Process

We've updated our access and security system. The first time you log in, enter your work email, and we'll guide you through the process.

  • If your organization uses Single Sign-On (SSO), you will be redirected to your company's login portal.
  • If you log in with a username and password, you will be prompted to set a new password before accessing your account.

Go to the Login Page to get started.

We appreciate your cooperation during this transition. If you need assistance, please call +1 650-552-4224 or email support@biocentury.com.

BioCentury
ARTICLE | Targets & Mechanisms

Greasing insulin

November 6, 2014 8:00 AM UTC

An entirely new class of fatty acids has just been discovered that potentially is more potent than the w-3 fatty acids found in fish oil. The new fatty acids-which work through G protein-coupled receptor 120, a target that had once been discarded by researchers-could be used to restore insulin sensitivity in patients with diabetes.1

G protein-coupled receptor 120 (GPR120; O3FAR1) was tapped as a potential obesity and diabetes target following a 2005 paper in Nature Medicine that showed the receptor triggered the release of glucagon-like peptide-1 (GLP-1) from intestinal cells when stimulated by unsaturated long-chain free fatty acids.2 But further studies showed that GPR120's direct effect on GLP-1 release would be minor or undetectable, and as a result companies abandoned the target in favor of related receptors that were able to stimulate insulin secretion...

Get Unlimited Access
Continue reading with a free trial.
Or Purchase This Article