Action Required: Password Reset on Next Login

As part of our recent security and system improvements, a password reset will be required the next time you log in. This applies to username/password users only; SSO users are not affected.

To reset your password, please visit the Reset Password page.

We appreciate your patience during this transition and are available to assist with any questions. For support, please call us at +1 650-552-4224 or email us at support@biocentury.com.

BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: MicroRNA-10b (miR-10b)

November 12, 2015 8:00 AM UTC

In vitro and mouse studies suggest an miR-10b inhibitor plus doxorubicin could help treat metastatic breast cancer. Levels of miR-10b were higher in human metastatic breast cancer cell lines and in primary tumors from patients with metastatic breast cancer than in non-metastatic breast cancer cells and tumors from patients with non-metastatic breast cancer, respectively. In human metastatic cancer cell lines, nanoparticles loaded with an anti-miR-10b antisense oligonucleotide plus IV doxorubicin decreased cell proliferation and increased apoptosis compared with either agent alone. In an orthotopic mouse model of metastatic breast cancer, the nanoparticle-doxorubicin combination caused complete regression of lymph node metastases in all treated animals. Next steps include testing the combination in breast cancer patients...

Get Unlimited Access
Continue reading with a free trial.
Or Purchase This Article