Armour: Relaxin in CRPC

Armour Therapeutics Inc.'s relaxin receptor antagonists may provide a complementary hormonal therapy that can be given either with or after anti-androgen therapy in prostate cancer patients. Targeting a secondary pathway alongside an androgen pathway could delay the time to when the disease becomes hormone refractory.

Prostate cancer therapies have predominantly targeted the androgen pathway, as aberrant androgen production drives tumor growth and metastases. These treatments include older therapies such as androgen hormone antagonists and newer compounds such as Zytiga abiraterone from Johnson & Johnson, which suppresses androgen synthesis, and Medivation Inc.'s enzalutamide, a next-generation androgen receptor antagonist...