ARTICLE | Emerging Company Profile
FPRT Bio: Neutralizing neuroinflammation
FPRT Bio's soluble TNF mimic blocks inflammation that drives ALS and PD
March 11, 2013 7:00 AM UTC
FPRT Bio Inc. is developing a protein therapeutic that could halt neurodegeneration in amyotrophic lateral sclerosis and Parkinson's disease by blocking inflammatory signaling that causes neuronal cell death.
FPRT's sole asset is XPro1595, a subcutaneously administered PEGylated protein that mimics soluble tumor necrosis factor (sTNF). Ordinarily, sTNF promotes inflammation by forming homotrimers that bind to TNF receptor 1 (TNFRSF1A; TNFR1; CD120a). XPro1595 blocks this inflammatory signaling by forming heterotrimers with sTNF that cannot bind TNFR1...