Musashi's dual duel
Musashi homolog 2 (MSI2) promotes cancer metastasis and therapy resistance
The Musashi genes were originally named for the samurai who fought with two swords because, when discovered in flies, their mutation created double-shafted bristles. Now, a pair of studies double down on the name, showing the genes play a key role in two aggressive cancers and could be exploited therapeutically or diagnostically.
In papers published in Nature and the Proceedings of the National Academy of Sciences, researchers from the University of California San Diego and the Fox Chase Cancer Center, respectively, showed the genes are major drivers in pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC). ...