Combo platter

In the last few years, Incyte Corp. has changed its strategy to incorporate combination options into the design and selection of its NCEs from the start. The company has developed an approach to target independent but intersecting pathways, and is gearing its activities to create a suite of compounds with a high ratio of synergistic possibilities.

Since January 2015, the company has expanded the number of targets in its portfolio from 4 to 11, using possibilities mapped out on paper and tested preclinically for their potential to work synergistically, rather than additively. ...