Mouse study shows iPS cells may elicit immune response

Researchers from the University of California, San Diego, published data in Nature showing that induced pluripotent stem (iPS) cells elicited an immune response when transplanted into the mice from which they were derived. In contrast, embryonic stem cells (ESCs) from the same mice did not produce an immune response. The authors attributed the immune response against iPS cells to the abnormal expression of antigens not expressed during normal development or differentiation of ESCs. ...