Therapeutics: HIV reverse transcriptase

INDICATION: HIV / AIDS

In vitro studies have identified indolylarylsulfone derivatives that could help treat HIV infection. In an infected human cell line, the compounds inhibited replication of wild-type and mutant HIV-1 strains at EC50 values less than 1 nM. Next steps could include optimizing the lead member of the series and evaluating it in animal models of HIV infection. ...