Therapeutics: Interleukin-6 (IL-6); RAR-related orphan receptor C (RORC; RORγ); interleukin-4 receptor (CD124; IL-4RA)

Patient sample and mouse studies suggest inhibiting IL-6 or RORC could help treat asthma patients harboring CD124 mutations. In Tregs from asthma patients, gain-of-function mutations in CD124 were ass...