Suppressing somatostatin
How Zucara's SSTR2 antagonists could prevent hypoglycemia in T1D patients
Zucara Therapeutics Inc. is developing somatostatin receptor 2 antagonists to prevent hypoglycemia in Type I diabetes patients without decreasing the efficacy of insulin therapy.
In Type I diabetes, somatostatin production is elevated, leading to continuous inhibition of glucagon. Glucagon inhibition in turn prevents patients from increasing and normalizing blood glucose levels following insulin therapy. ...
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