Cancer

In vitro studies suggest antagonizing the GHRH receptor could help treat retinoblastoma. In a human retinoblastoma cell line, GHRH receptor expression was higher than in normal eye-derived cell lines. In the retinoblastoma cell line and primary retinoblastoma cells, two GHRH receptor antagonist tool compounds increased apoptosis compared with vehicle; the compounds did not induce cell death in the normal cell lines. Next steps could include testing GHRH antagonists in animal models of retinoblastoma. ...