Cancer

Patient sample, cell culture and mouse studies suggest TRAIL-overexpressing adipose-derived stem cells could help treat glioblastoma multiforme (GBM). In GBM cells from patients, co-culture with human adipose-derived stem cells engineered to overexpress TRAIL increased apoptosis compared with co-culture with unmodified adipose stem cells. In an orthotopic xenograft mouse model of GBM, intratumoral injection of the TRAIL-overexpressing cells decreased tumor growth and microsatellite formation and increased survival. Next steps could include testing the TRAIL-overexpressing adipose-derived stem cells in additional GBM models...